Positron Emission Tomography–Magnetic Resonance Imaging (PET-MRI)
Positron Emission Tomography–Magnetic Resonance Imaging (PET-MRI) is a hybrid imaging technology that incorporates Magnetic Resonance Imaging (MRI) soft tissue morphological imaging, and Positron Emission Tomography (PET) molecular imaging. The technology combines the exquisite structural and functional characterization of tissue provided by MRI with the extreme sensitivity of PET imaging for the determination of receptor density/biological reaction rates/detection of radiolabelled drugs or vectors.
MR and PET acquisition can be made either separately or inline on individual MR and PET scanners, or simultaneously on bimodal machines. MR and PET images are then superimposed to provide single images with the characteristics of both technologies.
Read more on applications and used PET tracers here
Preclinical PET-MRI is provided by the following nodes:
- Austrian BioImaging / CMI (AT)
- Brain Imaging Network (PT)
- Center for Advanced Preclinical Imaging (CAPI) (CZ)
- Danish BioImaging (DK)
- Facility of Multimodal Imaging - AMMI Maastricht (NL)
- Finnish Biomedical Imaging Node (FI)
- Flanders BioImaging Node (BE)
- Medical and Preclinical Imaging Hungary (HU)
- Molecular Imaging Italian Node (IT)
- NORMOLIM (NO)
Human PET-MRI is provided by the following nodes:
- Brain Imaging Network (PT)
- Finnish Biomedical Imaging Node (FI)
- Flanders BioImaging Node (BE)
- Medical and Preclinical Imaging Hungary (HU)
- Molecular Imaging Italian Node (IT)
- Population Imaging Node Valencia (ES)
Use cases
| Use cases | Preclinical or human | Node | DOI |
|---|---|---|---|
| [11C]-tracers, investigation of the potential link between availability of specific neuroreceptors and transporters and gray matter density | Human | Finnish Biomedical Imaging Node | https://doi.org/10.1016/j.neuroimage.2021.117968 |
| [11C]-carfentanil, association of endogenous μ-opioid receptor (MOR) and neuronal rewards response to food picture | Human | Finnish Biomedical Imaging Node | https://doi.org/10.1038/s41467-018-03848-y |
| [11C](R)-PK11195, Evaluation of widespread Multiple Sclerosis | Human | Finnish Biomedical Imaging Node | https://doi.org/10.1212/NXI.0000000000000691 |
| [18F]FDG, Monitoring the side effects of radiation therapy in mice | Animal | HU Med & Preclinical Node | https://doi.org/10.1155/2018/5906471 |
| [18F]FDG, spinal cord | Human | Molecular Imaging Italian Node | https://doi.org/10.1002/mp.15149 |
| [18F]FDG, cancer | Human | Molecular Imaging Italian Node | https://doi.org/10.1007/s00277-021-04537-5https://doi.org/10.1007/s00259-020-04938-0 |
| [18F]FDG, injured brain imaging | Human | Molecular Imaging Italian Node | https://doi.org/10.3389/fneur.2018.00861 |